| CAS NO. |
124-94-7 (Base), 67-78-7 (Diacetate) |
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| EINECS NO. |
200-669-0 |
| FORMULA |
C25H31FO8 |
| MOL WT. |
478.51 |
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H.S. CODE
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TOXICITY
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| SYNONYMS |
Triamcinolone 16alpha,21-diacetate |
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16a,21-Diacetoxy-9a-fluoro-11b,17a-dihydroxy-1,4-pregnadiene-3,20-dione
9a-Fluoro-16a-hydroxyprednisolone 16,21-diacetate |
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SMILES |
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CLASSIFICATION
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PHYSICAL AND CHEMICAL PROPERTIES
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| PHYSICAL STATE |
white to off-white
crystalline powder |
| MELTING POINT |
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| BOILING POINT |
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| SPECIFIC GRAVITY |
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| SOLUBILITY IN WATER |
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| pH |
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| VAPOR DENSITY |
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REFRACTIVE INDEX
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NFPA RATINGS
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AUTOIGNITION
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FLASH POINT
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| STABILITY |
Stable under normal conditions. |
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GENERAL
DESCRIPTION & APPLICATIONS
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Triamcinolone is a synthetic steroid of the glucocorticoid family. It is a mimic of natural cortisol (hydrocortisone), acorticosteroid hormone produced by the adrenal cortex. Triamcinolone has a fluorine atom in stead of hydrogen at 9 position. It is used clinically as an anti-inflammatory and immunomodulator in a wide variety of conditions, including rashes, hemorrhoids, arthritis, and inflammatory bowel disease. It is used in the replacement therapy for adrenal insufficiency. Commercially available esters of triamcinolone include:
- Triamcinolone Benetonide [CAS #: 31002-79-6]
- Triamcinolone Furetonide [CAS #: 4989-94-0]
- Triamcinolone Hexacetonide [CAS #: 5611-51-8]
- Triamcinolone Diacetate [CAS #: 67-78-7]
- Triamcinolone Acetonide [CAS #: 76-25-5]
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| SALES SPECIFICATION |
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APPEARANCE
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white to off-white
crystalline powder |
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IDENTIFICATION
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Infrared absorption (conforms to USP)
Ultraviolet absorption (conforms to USP)
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ASSAY
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97.0
- 102.0% (Anhydrous Basis)
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WATER
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6.0% max
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HEAVY METALS
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20ppm max
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RESIDUE ON IGNITION
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0.5%
max
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SPECIFIC ROTATION |
+39° ~ +45°
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| TRANSPORTATION |
| PACKING |
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| HAZARD CLASS |
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| UN NO. |
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| OTHER INFORMATION |
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Hazard Symbols: XN, Risk Phrases: 40, Safety Phrases: 36/37-45 |
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GENERAL
DESCRIPTION OF CORTICOSTEROID
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Corticosteroid is a synthetic or naturally occurring 21-carbon steroid structure substances with four fused rings and vary functional branches attached to the ring system. Cholesterol and steroid hormones have this carbon skeleton. The term steroid refers to these three groups that contain a hydrogenated cyclopentano perhydro phenanthrene ring system. In restricted context for medical usage by non-endocrinologists, it refers to corticosteroids. Natural corticosteroids are elaborated by the adrenal cortex in response to physiological carbohydrate metabolism. According to their predominant biologic activity, they are divided into two major groups: glucocorticoid and mineralocorticoid. Glucocorticoid's chief function is to regulate carbohydrate, lipid, and protein metabolism and inhibit the release of ACTH (adrenocorticotropic hormone). Glucocorticoids also affect muscle tone and the microcirculation, participate in the maintenance of arterial blood pressure, increase gastric secretion, alter connective tissue response to injury, impede cartilage production, inhibit inflammatory, allergic, and immunologic responses, invoke shrinkage of lymphatic tissue, reduce the number of circulating lymphocytes, and affect the functions of the central nervous system. In humans, the most important ones are cortisol, cortisone, and corticosterone. Mineralocorticoids, uniuqely aldosterone in human, regulate the balance of water and promote retention of sodium, loss of potassium. Aldosterone plays a role also in promoting tissue repair. Spironolactone is the aldosterone antagonist called potassium-sparing diuretic used in the treatment of hypertension. Corticosteroids are used in clinically for hormonal replacement therapy, for suppression of ACTH, as antineoplastic, antiallergic, and anti-inflammatory agents, and to suppress immune responses.
- Glucocorticoid Receptor Agonists
- Dexamethasone
- Triamcinolone
- Hydrocortisone
- Prednisone
- Glucocorticoid Receptor Antagonists
- Mineralocorticoid Receptor Agonists
- Mineralocorticoid Receptor Antagonists
- Spironolactone
- Eplerenone
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